Katharine Diehl, Princeton University

Illuminating Epigenetic Mechanisms in Cancer with Designer Chromatin

In the eukaryotic cell, the genome is packaged in a nucleoprotein complex known as chromatin. Histones comprise the protein component of chromatin and serve as a hot bed for post-translational modifications (PTMs) that dynamically modulate local chromatin state to control DNA transcription, replication, and repair. Importantly, cancer cells depend on altered epigenetic landscapes to drive genomic instability and aberrant gene expression. In order to precisely target epigenetic misregulation in disease, it is critical to elucidate the mechanistic basis of how specific chromatin states are established and maintained. This talk will discuss how synthetic access to defined chromatin substrates enables the discovery of mechanisms by which histone PTMs modulate the genome. In the first part, a DNA-barcoded mononucleosome library was used to profile the activity of crucial DNA damage sensor enzymes (PARP1/2), uncovering new regulatory features in the DNA damage response. In the second part, designer chromatin substrates were used to investigate an oncogenic histone mutant, revealing details of how this mutation leads to deleterious epigenetic reprogramming. These efforts demonstrate how protein chemistry can be integrated with biochemical, biophysical, and genetic tools to facilitate analysis of the physicochemical principles underlying epigenetic dysregulation.
Chemistry

January 4, 2019
Kent 102 | Friday, 1:15 pm

More Information

Announcement

Marc-André Légaré, University of Würzburg

Main-Group Metallomimetics: Strategies for Metal-Free Catalysis and Small-Molecule Activation

This event is hosted by Professor Dmitri Talapin.
Chemistry

January 7, 2019
Kent 102 | Monday, 3:00 pm

More Information

Announcement

Reina Maruyama, Yale University

TBA


Physics Colloquium

January 10, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

Ke Xu, Department of Chemistry, University of California-Berkeley

Multifunctional & Multidimensional Super-resolution Microscopy

Recent advances in super-resolution fluorescence microscopy have led to ~10 nm spatial resolution and exciting new biology. We are developing new approaches to advance beyond the structural (shape) information offered by existing super-resolution methods, and reveal multidimensional information of intracellular functional parameters, including chemical polarity, diffusivity, and reactivity, with nanoscale resolution and single-molecule sensitivity. By adding remarkably rich functional dimensions to the already powerful super-resolution microscopy, we thus open up new ways to reveal fascinating local heterogeneities in live cells. Host: Bozhi Tian, 2-8749 or via email at btian@uchicago.edu. Persons with a disability who may need assistance please contact Brenda Thomas at 2-7156 or by email at bthomas@uchicago.edu.
The Tuesday JFI Seminar

January 15, 2019
GCIS W301 | Tuesday, 4:00 pm

More Information

Announcement

Margaret Gardel, University of Chicago


Computations in Science

January 16, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

TBA

TBA


Physics Colloquium

January 17, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

Shmuel Rubinstein, Harvard


Computations in Science

January 23, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

Pablo Jarillo-Herrero, Massachusetts Institute of Technology

TBA


Physics Colloquium

January 24, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

Jennifer Lippincott-Schwartz, HHMI

Peering Into Cells with New Imaging Technologies


Chemistry

January 28, 2019
Kent 120 | Monday, 4:00 pm

More Information

Announcement

Gurol Suel, University of California San Diego


Biophysical Dynamics

January 29, 2019
GCIS W301 | Tuesday, 12:00 pm

More Information

Announcement

Josh Vura-Weiss, Department of Chemistry - UIUC

Host: Andrei Tokmakoff, 4-7696 or via email to tokmakoff@uchicago.edu. Persons with a disability who may need assistance please contact Brenda Thomas at 2-7156 or by email at bthomas@uchicago.edu.
The Tuesday JFI Seminar

January 29, 2019
GCIS W301 | Tuesday, 4:00 pm

More Information

Announcement

Amy Weeks, University of California, San Francisco

New Chemoenzymatic Tools for Dissecting Proteolytic Signaling Pathways

This event is hosted by Professor Yamuna Krishnan.
Chemistry

January 30, 2019
GCIS W301 | Wednesday, 11:00 am

More Information

Announcement

TBA

TBA


Physics Colloquium

January 31, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

Andrej Košmrlj, Princeton University


Computations in Science

February 6, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

TBA

TBA


Physics Colloquium

February 7, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

Jörn Dunkel, MIT


Computations in Science

February 13, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

TBA

TBA


Physics Colloquium

February 14, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

Greg Voth, Wesleyan University


Computations in Science

February 20, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

TBA

TBA


Physics Colloquium

February 21, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

TBA

TBA


Physics Colloquium

February 28, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

TBA

TBA


Physics Colloquium

March 7, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

TBA

TBA


Physics Colloquium

March 14, 2019
KPTC 106 | Thursday, 4:00 pm

More Information

Announcement

Hana El-Samad, University of California, San Francisco


Computations in Science

March 20, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

IME Distinguished Colloquium Series - Alberto Salleo

Professor Alberto Salleo from Stanford University will speak as part of the IME Distinguished Colloquium Series.

Event will be followed by a reception from 5 pm to 6 pm at ERC in IME’s 2nd floor lounge/atrium area
Molecular Engineering

March 20, 2019
KCBD 1103 | Wednesday, 4:00 pm

More Information

Announcement

Arvind Murugan, University of Chicago


Computations in Science

March 27, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

Greg Bewley, Cornell University


Computations in Science

April 3, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

Oskar Hallatschek, UC Berkeley


Computations in Science

April 10, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

IME Distinguished Colloquium Series - Rohit Karnik

Professor Rohit Karnik from Massachusetts Institute of Technology will speak as part of the IME Distinguished Colloquium Series.

Event will be followed by a reception from 5 pm to 6 pm at ERC in IME’s 2nd floor lounge/atrium area
Molecular Engineering

April 10, 2019
KCBD 1103 | Wednesday, 4:00 pm

More Information

Announcement

Nikta Fakhri, MIT


Computations in Science

April 17, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

Detlef Lohse, University of Twente


Computations in Science

April 24, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

IME Distinguished Colloquium Series - Jeffrey Moore

Professor Jeffrey Moore from University of Illinois will speak as part of the IME Distinguished Colloquium Series.

Event will be followed by a reception from 5 pm to 6 pm at ERC in IME’s 2nd floor lounge/atrium area
Molecular Engineering

April 24, 2019
KCBD 1103 | Wednesday, 4:00 pm

More Information

Announcement

Pankaj Mehta, Boston University


Computations in Science

May 1, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

Thierry Emonet, Yale University


Computations in Science

May 8, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

IME Distinguished Colloquium Series - Darrell Irvine

Professor Darrell Irvine from Massachusetts Institute of Technology will speak as part of the IME Distinguished Colloquium Series.

Event will be followed by a reception from 5 pm to 6 pm at ERC in IME’s 2nd floor lounge/atrium area
Molecular Engineering

May 8, 2019
KCBD 1103 | Wednesday, 4:00 pm

More Information

Announcement

David Lentik, Stanford


Computations in Science

May 15, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

Joshua Shaevitz, Princeton University


Computations in Science

May 22, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

IME Distinguished Colloquium Series - Sven Rogge

Professor Sven Rogge from the University of New South Wales will speak as part of the IME Distinguished Colloquium Series.

Event will be followed by a reception from 5 pm to 6 pm at ERC in IME’s 2nd floor lounge/atrium area
Molecular Engineering

May 22, 2019
KCBD 1103 | Wednesday, 4:00 pm

More Information

Announcement

Xiaoming Mao, University of Michigan


Computations in Science

May 29, 2019
KPTC 206 | Wednesday, 12:15 pm

More Information

Announcement

IME Distinguished Colloquium Series - Ralph Colby

Professor Ralph Colby from Penn State University will speak as part of the IME Distinguished Colloquium Series.

Event will be followed by a reception from 5 pm to 6 pm at ERC in IME’s 2nd floor lounge/atrium area
Molecular Engineering

June 5, 2019
KCBD 1103 | Wednesday, 4:00 pm

More Information

Announcement

Top