Gardel Lab Publications

2012  I 2011  I   2010  I  2009  I  2008  I  Pre-2007

2012

Lenz M, Thoresen T, Gardel ML and Dinner AR, “Contractile units in disordered actomyosin bundles arise from F-actin buckling”,Physical Review Letters, 108, 238107 (2012) (link) (pdf)

Falzone TT, Lenz M, Kovar DR, Gardel ML, "Assembly kinetics determine the architecture of a-actinin crosslinked F-actin networks", Nature Communications, 3:861 (2012) (link) (pdf)

Lenz M, Gardel ML and Dinner AR, “Requirements for disordered actomyosin bundle contractility”, New J. Phys., 14, 033037 (2012) (link) (pdf)

Oakes P, Beckham Y, Stricker J and Gardel ML, “Tension is required but not sufficient for focal adhesion maturation without a stress fiber template”,Journal of Cell Biology, 196 (3) (2012) (PMID: 22291038) (pdf)
(Highlighted In Focus: Stress Fibers guide focal adhesions to maturity, selected for F1000 )

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2011

Spatiotemporal Constraints on the Force-Dependent Growth of Focal Adhesions. Stricker J, Aratyn-Schaus Y, Oakes P and Gardel ML. Biophysical Journal, 100(12): 2883-93 (2011) (PMID: 21689521) (pdf)

Reconstitution of Contractile Actomyosin Bundles. Thoresen T, Lenz M, Gardel ML, Biophysical Journal, (100)11:2698-705 (2011) (PMID: 21641315) (pdf)

Dynamic and Structural Signatures of Lamellar Actomyosin Force Generation. Aratyn-Schaus Y, Oakes PW, Gardel ML. Molecular Biology of the Cell. 22: 1330-1339 (2011) (PMID: 21307339) (pdf)

Cell-ECM Traction Force Modulates Endogenous Tension at Cell-Cell Contacts. Maruthamuthu V, Sabass B, Schwarz U. Gardel ML. Proc Natl Acad Sci U S A: 12: 4708-13 (2011) (PMID: 21383129) (pdf)
(selected for F1000 )

Shear thickening of F-actin networks crosslinked with non-muscle myosin IIB. Norstrom, M and Gardel, ML. Soft Matter. 2011. (pdf)

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2010

Preparation of compliant matrices for quantifying cellular contraction. Aratyn-Schaus Y, Oakes PW, Stricker J, Winter SP, Gardel ML. J. Vis Exp.. 2010 Dec 14; (46). (PMID: 21178972) (pdf) (video)

A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Smith MA, Blankman E, Gardel ML, Luettjohann L, Waterman CM, Beckerle MC. Developmental Cell. 2010 Sep 14; 19(3): 365-76. (PMID: 20833360)

Conserved F-actin dynamics and force transmission at cell adhesions. Maruthamuthu V, Aratyn-Schaus Y, Gardel ML. Curr Opin Cell Biol. 2010 Aug 19. [Epub ahead of print] (PMID: 20728328)

Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration. Gardel ML, Schneider IC, Aratyn-Schaus Y, Waterman CM. Annu Rev Cell Dev Biol. 2010 May 17. [Epub ahead of print] (PMID: 19575647)

Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions. Borghi N, Lowndes M, Maruthamuthu V, Gardel ML, Nelson WJ. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13324-9. (PMID: 20566866)

Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension. Aratyn-Schaus Y, Gardel ML. Curr Biol. 2010 Jul 13;20(13):1145-53. (PMID: 20541412) (pdf)
(in the same issue see also dispatch: Cell–Matrix Adhesion: Slip and Immobilization under Force. Verkhovsky AB. doi:10.1016/j.cub.2010.06.030)

Optimization of traction force microscopy for micron-sized focal adhesions. Stricker J, Sabass B, Schwarz US, Gardel ML. J Phys Condens Matter. 2010 Apr 26;22(19):194104. (PMID: 20523913) (pdf)

Mechanics of the F-actin cytoskeleton. Stricker J, Falzone T, Gardel ML. J Biomech. 2010 Jan 5;43(1):9-14. (PMID: 19913792) (pdf)

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2009

Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly. Rizvi SA, Neidt EM, Cui J, Feiger Z, Skau CT, Gardel ML, Kozmin SA, Kovar DR. Chem Biol. 2009 Nov 25;16(11):1158-68. (PMID: 19942139)

Local cortical tension by myosin II guides 3D endothelial cell branching. Fischer RS, Gardel M, Ma X, Adelstein RS, Waterman CM. Curr Biol. 2009 Feb 10;19(3):260-5. (PMID: 19185493)

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2008

Biophysics. Clutch dynamics. Aratyn-Schaus Y, Gardel ML. Science. 2008 Dec 12;322(5908):1646-7. (PMID: 19074337) (pdf)

Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. Gardel ML, Sabass B, Ji L, Danuser G, Schwarz US, Waterman CM. J Cell Biol. 2008 Dec 15;183(6):999-1005. (PMID: 19075110)
(see also commentary: The actin flow paradox.Williams R. JCB 2008 vol. 183 no. 6965)

Chapter 19: Mechanical response of cytoskeletal networks. Gardel ML, Kasza KE, Brangwynne CP, Liu J, Weitz DA. Methods Cell Biol. 2008;89:487-519. (PMID: 19118688) (pdf)

High resolution traction force microscopy based on experimental and computational advances. Sabass B, Gardel ML, Waterman CM, Schwarz US. Biophys J. 2008 Jan 1;94(1):207-20. (PMID: 17827246) (pdf)

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility. Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, Chen XL, Uryu SA, Canete-Soler R, Zhai J, Lin H, Schlaepfer WW, Nalbant P, Bokoch G, Ilic D, Waterman-Storer C, Schlaepfer DD. J Cell Biol. 2008 Jan 14;180(1):187-203. (PMID: 18195107) (pdf)

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Pre-2007

CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. Féral CC, Zijlstra A, Tkachenko E, Prager G, Gardel ML, Slepak M, Ginsberg MH. J Cell Biol. 2007 Aug 13;178(4):701-11. (PMID: 17682053) (pdf)

Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1762-7. (PMID: 16446458) (pdf)

Stress-dependent elasticity of composite actin networks as a model for cell behavior. Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA. Phys Rev Lett. 2006 Mar 3;96(8):088102. (PMID: 16606229) (pdf)

Microrheology probes length scale dependent rheology. Liu J, Gardel ML, Kroy K, Frey E, Hoffman BD, Crocker JC, Bausch AR, Weitz DA. Phys Rev Lett. 2006 Mar 24;96(11):118104. (PMID: 16605878) (pdf)

Scaling of F-actin network rheology to probe single filament elasticity and dynamics. Gardel ML, Shin JH, MacKintosh FC, Mahadevan L, Matsudaira PA, Weitz DA. Phys Rev Lett. 2004 Oct 29;93(18):188102. (PMID: 15525211) (pdf)

Elastic behavior of cross-linked and bundled actin networks. Gardel ML, Shin JH, MacKintosh FC, Mahadevan L, Matsudaira P, Weitz DA. Science. 2004 May 28;304(5675):1301-5. (PMID: 15166374) (pdf)

Relating microstructure to rheology of a bundled and cross-linked F-actin network in vitro. Shin JH, Gardel ML, Mahadevan L, Matsudaira P, Weitz DA. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9636-41. (PMID: 15210969) (pdf)

Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA. Biophys J. 2004 Jun;86(6):4004-14. (PMID: 15189896) (pdf)

Anomalous diffusion probes microstructure dynamics of entangled F-actin networks. Wong IY, Gardel ML, Reichman DR, Weeks ER, Valentine MT, Bausch AR, Weitz DA. Phys Rev Lett. 2004 Apr 30;92(17):178101. (PMID: 15169197) (pdf)

Microrheology of entangled F-actin solutions. Gardel ML, Valentine MT, Crocker JC, Bausch AR, Weitz DA. Phys Rev Lett. 2003 Oct 10;91(15):158302. (PMID: 14611506) (pdf)

Microrheology. Gardel ML, Valentine MT, Weitz DA. Microscale Diagnostic Techniques. 2005 K. Breuer (ed) Springer Verlag. (pdf)

Measuring the mechanical stress induced by an expanding multicellular tumor system: a case study. Gordon VD, Valentine MT, Gardel ML, Andor-Ardó D, Dennison S, Bogdanov AA, Weitz DA, Deisboeck TS. Exp Cell Res. 2003 Sep 10;289(1):58-66. (PMID: 12941604) (pdf)

Giant dielectric constant response in a copper-titanate. Ramirez AP, Subramanian MA, Gardel M, Blumberg G, Li D, Vogt T, Shapiro SM. Solid State Communications. 2000 115: 217-220.

Electron detachment and fragmentation in collisions between 1.25 keV/carbon C8- and C60- clusters and H2. Gardel ML, Vandenbosch R, Henry BP, Cooper C, Will DI. European Physical Journal. 1999 D, 7: 79-81.

Long Wavelength Spin Dynamics in La0.53Ca0.47MnO3. Rhyne JJ, Kaiser H, Luo H, Xiao G, and Gardel ML. J Applied Physics. 1998 83: 7339-7341.

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Margaret Gardel's Office University of Chicago Gordon Center for Integrative Science, GCIS E233 929 E. 57th St, Chicago, IL 60637 ph: (773) 834-5871   fax: (773) 834-0406 email:

Laboratory University of Chicago Gordon Center for Integrative Science, GCISW 309 + 314 929 E. 57th St, Chicago, IL 60637 ph: (773) 834-9160   fax: (773) 834-1917